p27Cip/Kip Is Involved in Hsp25 or Inducible Hsp70 Mediated Adaptive Response by Low Dose Radiation

p27Cip/Kip is involved in hsp25 or inducible hsp70 mediated adaptive response by low dose radiation.

Thermoresistant (TR) clone of radiation-induced fibrosarcoma (RIF) cells have been reported to show adaptive response to 1 cGy of low dose radiation, and hsp25 and inducible hsp70 are involved in this process. In the present study, to further elucidate the mechanism of how hsp25 and inducible hsp70 regulate the adaptive response, hsp25 or inducible hsp70 overexpressed RIF cells were irradiated ...

INVOLVEMENT OF p27CIP/KIP IN HSP25 OR INDUCIBLE HSP70 MEDIATED ADAPTIVE RESPONSE BY LOW DOSE RADIATION

HANG-RHAN SEO, HEE-YONG CHUNG, YOON-JIN LEE, MIN BAEK, SANGWOO BAE, SU-JAE LEE and YUN-SIL LEE Laboratory of Radiation Effect and Laboratory of Radiation Experimental Therapeutics, Korea Institute of Radiological and Medical Sciences, Seoul, 139-706, Korea, Department of Microbiology, College of Medicine, Hanyang University, Seoul 133-791, Korea Atomic Energy Policy Division, Atomic Energy Bure...

Low Dose Radiation Response in the Lungs and Spleen Low Dose Radiation Response in the Lungs and Spleen

Tumor suppressor p53 response is blunted by low-dose-rate radiation

INTRODUCTION Modulation of gene expression in response to ionizing radiation is of prime interest in the field of radiation biology. In most articles concerning biological responses to ionizing radiation, the findings of radiation-induced gene expression after irradiation at a lethal dose range (2-50 Gy) has been reported. Recently, the biological effect of low dose radiation on cellular respon...

Radiation hormesis and adoptive response induced by low doses of limiting radiation

  Ionizing radiation has long been known to produce detrimental biological effects. Although these harmful effects are the results of high doses of exposure, some other maladies such as mutation and cancer seems  to be induced at low doses of exposure. In recent decades, however, some pioneer scientists have indicated that ionizing radiation like many other essential agents has toxic effects  ...